{"entity":{"id":"ap3b1","kind":"target","name":"AP3B1","aka":["adaptor related protein complex 3 subunit beta 1","AP-3 complex subunit beta-1","ADTB3A","HPS2"],"tldr":"AP3B1 (AP-3 complex subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.19, genetic association 0.00, somatic mutation 0.23, animal model 0.48).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:566","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:566"},{"label":"UniProt O00203","url":"https://www.uniprot.org/uniprotkb/O00203/entry"},{"label":"NCBI Gene 8546","url":"https://www.ncbi.nlm.nih.gov/gene/8546"},{"label":"Ensembl ENSG00000132842","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000132842"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AP3B1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:566","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:566","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O00203","url":"https://www.uniprot.org/uniprotkb/O00203/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000132842","url":"https://platform.opentargets.org/target/ENSG00000132842/associations","note":"association with cancer (MONDO_0004992) 0.58;  (GraphQL API, CC0)"}],"hgnc":"HGNC:566","ensembl":"ENSG00000132842","uniprot":"O00203","entrez":"8546","biology":"Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Location: Cytoplasmic vesicle, clathrin-coated vesicle membrane; Golgi apparatus (UniProt). Locus 5q14.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ap3b1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}