{"entity":{"id":"apbb1ip","kind":"target","name":"APBB1IP","aka":["amyloid beta precursor protein binding family B member 1 interacting protein","Amyloid beta A4 precursor protein-binding family B member 1-interacting protein","RARP1","PREL1","INAG1"],"tldr":"APBB1IP (Amyloid beta A4 precursor protein-binding family B member 1-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.79, affected pathway 0.97, animal model 0.50, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17379","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17379"},{"label":"UniProt Q7Z5R6","url":"https://www.uniprot.org/uniprotkb/Q7Z5R6/entry"},{"label":"NCBI Gene 54518","url":"https://www.ncbi.nlm.nih.gov/gene/54518"},{"label":"Ensembl ENSG00000077420","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000077420"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"APBB1IP","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:17379","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17379","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7Z5R6","url":"https://www.uniprot.org/uniprotkb/Q7Z5R6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000077420","url":"https://platform.opentargets.org/target/ENSG00000077420/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:17379","ensembl":"ENSG00000077420","uniprot":"Q7Z5R6","entrez":"54518","biology":"Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. Location: Cell membrane; Cell projection, lamellipodium; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 10p12.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/apbb1ip/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}