{"entity":{"id":"aptn-101","kind":"drug","name":"APTN-101","aka":["hEGFRvIII-CD3 bi-scFv","EGFRvIII BRiTE"],"tldr":"APTN-101 is a two-armed antibody from Adaptin Bio that steers a patient's own T cells against brain tumour cells carrying a faulty growth receptor. It is in a first trial in people with glioblastoma at Duke University.","summary":"APTN-101 is Adaptin Bio's EGFRvIII x CD3 bispecific (BRiTE). The FDA accepted an investigator-initiated IND for a single-dose trial in May 2023 and a multi-dose amendment in October 2025; institutional review board approval for the multi-dose trial in glioblastoma came in March 2026, and Duke University opened the investigator-initiated phase 1 trial, \"A Phase I Study of hEGFRvIII-CD3 bi-scFv (BRiTE) in Patients with WHO Grade IV Malignant Glioma\", in August 2026.","status":"phase-1","asOf":"2026-11-04","links":[{"label":"SEC: Adaptin Bio Form S-1, August 2026","url":"https://www.sec.gov/Archives/edgar/data/1938571/000121390026095034/ea0303043-s1_adaptin.htm"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":[],"technologies":["t-cell-engager"],"targets":["cd3"],"drugs":[],"companies":["adaptin-bio"],"institutions":[],"pathways":[],"terms":["egfrviii"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors","editedOn":"2026-11-04"},"code":"APTN-101","modality":"Bispecific T cell engager (EGFRvIII x CD3)","mechanism":"A fully human bispecific single-chain antibody that binds EGFRvIII, a mutant form of EGFR found on tumour cells, and CD3 on T cells, redirecting the patient's T cells to kill the tumour; Adaptin Bio's BRiTE approach uses activated T cells to carry it into the brain.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/aptn-101/","neighbours":{"technology":[{"id":"t-cell-engager","kind":"technology","name":"T-cell engagers (bispecific)","route":"/technologies/t-cell-engager/"}],"target":[{"id":"cd3","kind":"target","name":"CD3","route":"/targets/cd3/"}],"company":[{"id":"adaptin-bio","kind":"company","name":"Adaptin Bio","route":"/companies/adaptin-bio/"}],"term":[{"id":"egfrviii","kind":"term","name":"EGFRvIII","route":"/terms/egfrviii/"}]}}