{"entity":{"id":"areg","kind":"target","name":"AREG","aka":["amphiregulin","Amphiregulin","CRDGF","AREGB"],"tldr":"AREG (Amphiregulin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Head and neck squamous cell carcinoma and Non-small-cell lung cancer.","summary":"Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.\n\nCIViC holds 5 clinical evidence items and 0 assertions across 2 variants, naming Crizotinib, Cetuximab, Panitumumab and Docetaxel. Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.73, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:651","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:651"},{"label":"UniProt P15514","url":"https://www.uniprot.org/uniprotkb/P15514/entry"},{"label":"NCBI Gene 374","url":"https://www.ncbi.nlm.nih.gov/gene/374"},{"label":"Ensembl ENSG00000109321","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000109321"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["colorectal","head-and-neck","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 5 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AREG","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:651","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:651","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P15514","url":"https://www.uniprot.org/uniprotkb/P15514/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene AREG","url":"https://civicdb.org/features/389","note":"5 evidence items, 0 assertions, 2 variants; diseases: Lung Non-small Cell Carcinoma, Colorectal Cancer, Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000109321","url":"https://platform.opentargets.org/target/ENSG00000109321/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:651","ensembl":"ENSG00000109321","uniprot":"P15514","entrez":"374","biology":"Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. Location: Membrane (UniProt). Locus 4q13.3 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease","Head and neck squamous cell carcinoma: CIViC evidence names this disease","Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/areg/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}