{"entity":{"id":"argos-therapeutics","kind":"company","name":"Argos Therapeutics","aka":["Argos Therapeutics, Inc.","Argos"],"tldr":"Argos was a North Carolina company whose personalised dendritic-cell vaccine rocapuldencel-T, made from each patient's own tumour RNA, failed the phase 3 ADAPT trial in kidney cancer and the company closed in 2019.","summary":"Argos Therapeutics, founded in 1997 in Durham, North Carolina, built the Arcelis platform, which loaded a patient's dendritic cells with RNA amplified from their own tumour. Rocapuldencel-T (AGS-003) was tested with sunitinib in the phase 3 ADAPT trial in metastatic renal cell carcinoma; the trial was stopped for futility in 2017 and the company filed for bankruptcy in 2019. Its trials remain on ClinicalTrials.gov under Argos as lead sponsor.","asOf":"2026-09-11","links":[{"label":"Official website","url":"http://www.argostherapeutics.com"},{"label":"ClinicalTrials.gov: trials led by Argos Therapeutics, Inc.","url":"https://clinicaltrials.gov/search?lead=Argos%20Therapeutics%2C%20Inc."},{"label":"Wikidata","url":"https://www.wikidata.org/wiki/Q30286762"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["rcc"],"sections":[],"technologies":["dendritic-cell-vaccines"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["pivotal-trial","clinical-trial"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"Durham, NC","country":"US","companyType":"cell-therapy","website":"http://www.argostherapeutics.com","founded":1997,"stage":"defunct","investors":[],"funding":[]},"route":"/companies/argos-therapeutics/","neighbours":{"cancer":[{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}],"technology":[{"id":"dendritic-cell-vaccines","kind":"technology","name":"Dendritic cell vaccines","route":"/technologies/dendritic-cell-vaccines/"}],"term":[{"id":"clinical-trial","kind":"term","name":"Clinical trial","route":"/terms/clinical-trial/"},{"id":"pivotal-trial","kind":"term","name":"Pivotal (registrational) trial","route":"/terms/pivotal-trial/"}]}}