{"entity":{"id":"arhgap26","kind":"target","name":"ARHGAP26","aka":["Rho GTPase activating protein 26","Rho GTPase-activating protein 26","KIAA0621","OPHN1L","OPHN1L1"],"tldr":"ARHGAP26 (Rho GTPase-activating protein 26) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Leukaemia and 2 more.","summary":"GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V.\n\nOpen Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.92, genetic association 0.51, somatic mutation 0.90, animal model 0.32).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17073","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17073"},{"label":"UniProt Q9UNA1","url":"https://www.uniprot.org/uniprotkb/Q9UNA1/entry"},{"label":"NCBI Gene 23092","url":"https://www.ncbi.nlm.nih.gov/gene/23092"},{"label":"Ensembl ENSG00000145819","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145819"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["gastric","breast-cancer","leukaemia","myeloproliferative-neoplasms","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARHGAP26","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:17073","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17073","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UNA1","url":"https://www.uniprot.org/uniprotkb/Q9UNA1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000145819","url":"https://platform.opentargets.org/target/ENSG00000145819/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: gastric cancer 0.55, skin cancer 0.51, myeloproliferative neoplasm 0.52, breast cancer 0.54, leukaemia 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:17073","ensembl":"ENSG00000145819","uniprot":"Q9UNA1","entrez":"23092","biology":"GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesised proteins. Location: Endosome membrane; Cytoplasm; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 5q31.3 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: Open Targets association 0.55 with gastric cancer (MONDO_0001056)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.52 with myeloproliferative neoplasm (MONDO_0020076)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)"],"targetClass":"other","prevalence":[]},"route":"/targets/arhgap26/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}