{"entity":{"id":"arhgap5","kind":"target","name":"ARHGAP5","aka":["Rho GTPase activating protein 5","Rho GTPase-activating protein 5","RhoGAP5","p190-B","p190BRhoGAP","GFI2"],"tldr":"ARHGAP5 (Rho GTPase-activating protein 5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Multiple myeloma, Pancreatic ductal adenocarcinoma and 4 more.","summary":"GTPase-activating protein for Rho family members.\n\nIntOGen calls it a driver in 7 cohorts (3 activating, 4 loss-of-function), covering Bladder Urothelial Carcinoma, Pancreatic Adenocarcinoma, Plasma Cell Myeloma, Pleural Mesothelioma, Well-Differentiated Thyroid Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:675","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:675"},{"label":"UniProt Q13017","url":"https://www.uniprot.org/uniprotkb/Q13017/entry"},{"label":"NCBI Gene 394","url":"https://www.ncbi.nlm.nih.gov/gene/394"},{"label":"Ensembl ENSG00000100852","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100852"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["urothelial","multiple-myeloma","pancreatic","mesothelioma","thyroid","pleural-mesothelioma","papillary-thyroid-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARHGAP5","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:675","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:675","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13017","url":"https://www.uniprot.org/uniprotkb/Q13017/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ARHGAP5","url":"https://www.intogen.org/search?gene=ARHGAP5","note":"driver in 7 cohorts (Act 3, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:675","ensembl":"ENSG00000100852","uniprot":"Q13017","entrez":"394","biology":"GTPase-activating protein for Rho family members. Location: Cytoplasm; Cell membrane (UniProt). Locus 14q12 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 2 cohorts (BLCA)","Multiple myeloma: IntOGen driver in 2 cohorts (PCM)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)","Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Thyroid cancer: IntOGen driver in 1 cohort (WDTC)","Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/arhgap5/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"papillary-thyroid-cancer","kind":"cancer","name":"Papillary thyroid cancer","route":"/cancers/papillary-thyroid-cancer/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}