{"entity":{"id":"arhgef10","kind":"target","name":"ARHGEF10","aka":["Rho guanine nucleotide exchange factor 10","KIAA0294","Gef10"],"tldr":"ARHGEF10 (Rho guanine nucleotide exchange factor 10) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Cutaneous squamous cell carcinoma, Non-small-cell lung cancer and 1 more.","summary":"May play a role in developmental myelination of peripheral nerves.\n\nIntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Bladder Urothelial Carcinoma, Cutaneous Squamous Cell Carcinoma, Non-Small Cell Lung Cancer, Small Cell Lung Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14103","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14103"},{"label":"UniProt O15013","url":"https://www.uniprot.org/uniprotkb/O15013/entry"},{"label":"NCBI Gene 9639","url":"https://www.ncbi.nlm.nih.gov/gene/9639"},{"label":"Ensembl ENSG00000104728","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104728"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["urothelial","cutaneous-scc","nsclc","sclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARHGEF10","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:14103","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14103","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15013","url":"https://www.uniprot.org/uniprotkb/O15013/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ARHGEF10","url":"https://www.intogen.org/search?gene=ARHGEF10","note":"driver in 4 cohorts (Act 1, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:14103","ensembl":"ENSG00000104728","uniprot":"O15013","entrez":"9639","biology":"May play a role in developmental myelination of peripheral nerves. Locus 8p23.3 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Cutaneous squamous cell carcinoma: IntOGen driver in 1 cohort (CSCC)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (NSCLC)","Small-cell lung cancer: IntOGen driver in 1 cohort (SCLC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/arhgef10/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"cutaneous-scc","kind":"cancer","name":"Cutaneous squamous cell carcinoma","route":"/cancers/cutaneous-scc/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}]}}