{"entity":{"id":"arhgef10l","kind":"target","name":"ARHGEF10L","aka":["Rho guanine nucleotide exchange factor 10 like","Rho guanine nucleotide exchange factor 10-like protein","FLJ10521","KIAA1626"],"tldr":"ARHGEF10L (Rho guanine nucleotide exchange factor 10-like protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Basal cell carcinoma and Clear cell renal cell carcinoma.","summary":"Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.\n\nIntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Basal Cell Carcinoma, Renal Clear Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25540","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25540"},{"label":"UniProt Q9HCE6","url":"https://www.uniprot.org/uniprotkb/Q9HCE6/entry"},{"label":"NCBI Gene 55160","url":"https://www.ncbi.nlm.nih.gov/gene/55160"},{"label":"Ensembl ENSG00000074964","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000074964"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["rcc","basal-cell-carcinoma","clear-cell-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARHGEF10L","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:25540","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25540","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HCE6","url":"https://www.uniprot.org/uniprotkb/Q9HCE6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ARHGEF10L","url":"https://www.intogen.org/search?gene=ARHGEF10L","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:25540","ensembl":"ENSG00000074964","uniprot":"Q9HCE6","entrez":"55160","biology":"Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. Location: Cytoplasm (UniProt). Locus 1p36.13 (HGNC).","whereFound":["Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)","Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)","Clear cell renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/arhgef10l/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"clear-cell-rcc","kind":"cancer","name":"Clear cell renal cell carcinoma","route":"/cancers/clear-cell-rcc/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}