{"entity":{"id":"arhgef5","kind":"target","name":"ARHGEF5","aka":["Rho guanine nucleotide exchange factor 5","TIM1","GEF5","P60"],"tldr":"ARHGEF5 (Rho guanine nucleotide exchange factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.82, genetic association 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13209","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13209"},{"label":"UniProt Q12774","url":"https://www.uniprot.org/uniprotkb/Q12774/entry"},{"label":"NCBI Gene 7984","url":"https://www.ncbi.nlm.nih.gov/gene/7984"},{"label":"Ensembl ENSG00000050327","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000050327"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARHGEF5","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:13209","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13209","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q12774","url":"https://www.uniprot.org/uniprotkb/Q12774/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000050327","url":"https://platform.opentargets.org/target/ENSG00000050327/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: breast cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:13209","ensembl":"ENSG00000050327","uniprot":"Q12774","entrez":"7984","biology":"Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organisation. Plays a role in actin organisation by generating a loss of actin stress fibres and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Location: Cytoplasm; Nucleus; Cell projection, podosome (UniProt). Locus 7q35 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.50 with breast cancer (MONDO_0007254)"],"targetClass":"other","prevalence":[]},"route":"/targets/arhgef5/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}