{"entity":{"id":"arid1b","kind":"target","name":"ARID1B","aka":["AT-rich interaction domain 1B","AT-rich interactive domain-containing protein 1B","KIAA1235","ELD/OSA1","p250R","BAF250b","DAN15","6A3-5","SMARCF2"],"tldr":"ARID1B (AT-rich interactive domain-containing protein 1B) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Colorectal cancer, Renal cell carcinoma and 5 more.","summary":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes affected pathway 0.29, literature 0.94, genetic association 0.30, somatic mutation 0.95, animal model 0.46). IntOGen calls it a driver in 22 cohorts (4 activating, 16 loss-of-function), covering Angiosarcoma, Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Renal Clear Cell Carcinoma, Cervical Adenocarcinoma, Colorectal Adenocarcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18040","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18040"},{"label":"UniProt Q8NFD5","url":"https://www.uniprot.org/uniprotkb/Q8NFD5/entry"},{"label":"NCBI Gene 57492","url":"https://www.ncbi.nlm.nih.gov/gene/57492"},{"label":"Ensembl ENSG00000049618","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000049618"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["breast-cancer","colorectal","rcc","endometrial","urothelial","cervical","hcc","non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 16 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARID1B","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18040","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18040","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8NFD5","url":"https://www.uniprot.org/uniprotkb/Q8NFD5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ARID1B","url":"https://civicdb.org/features/13820","note":"1 evidence items, 0 assertions, 1 variants; diseases:  (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000049618","url":"https://platform.opentargets.org/target/ENSG00000049618/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.56, ovarian cancer 0.55, endometrial cancer 0.53, melanoma 0.55, skin cancer 0.56, breast cancer 0.59 (GraphQL API, CC0)"},{"label":"IntOGen ARID1B","url":"https://www.intogen.org/search?gene=ARID1B","note":"driver in 22 cohorts (Act 4, LoF 16); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18040","ensembl":"ENSG00000049618","uniprot":"Q8NFD5","entrez":"57492","biology":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). Location: Nucleus (UniProt). Locus 6q25.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.59 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)","Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575); IntOGen driver in 2 cohorts (COADREAD)","Renal cell carcinoma: IntOGen driver in 2 cohorts (CCRCC, PRCC)","Endometrial cancer: Open Targets association 0.53 with endometrial cancer (MONDO_0011962); IntOGen driver in 1 cohort (UCEC)","Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Cervical cancer: IntOGen driver in 1 cohort (CEAD)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/arid1b/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}