{"entity":{"id":"arid2","kind":"target","name":"ARID2","aka":["AT-rich interaction domain 2","AT-rich interactive domain-containing protein 2","KIAA1557","DKFZp686G052","FLJ30619","BAF200","SMARCF3","ZIPZAP","p200"],"tldr":"ARID2 (AT-rich interactive domain-containing protein 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Hepatocellular carcinoma, Oesophageal cancer and 5 more.","summary":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.98). IntOGen calls it a driver in 36 cohorts (3 activating, 33 loss-of-function), covering Cholangiocarcinoma, Cutaneous Squamous Cell Carcinoma, Oesophageal Adenocarcinoma, Oesophageal Squamous Cell Carcinoma, Glioblastoma, Gallbladder Cancer and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18037","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18037"},{"label":"UniProt Q68CP9","url":"https://www.uniprot.org/uniprotkb/Q68CP9/entry"},{"label":"NCBI Gene 196528","url":"https://www.ncbi.nlm.nih.gov/gene/196528"},{"label":"Ensembl ENSG00000189079","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000189079"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["skin-cancer","hcc","esophageal","gastric","biliary-tract-cancer","head-and-neck","nasopharyngeal","ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 33 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARID2","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18037","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18037","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q68CP9","url":"https://www.uniprot.org/uniprotkb/Q68CP9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ARID2","url":"https://civicdb.org/features/19838","note":"1 evidence items, 0 assertions, 2 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000189079","url":"https://platform.opentargets.org/target/ENSG00000189079/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.53, oesophageal cancer 0.57, hepatocellular carcinoma 0.63, melanoma 0.72, skin cancer 0.67, lung cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen ARID2","url":"https://www.intogen.org/search?gene=ARID2","note":"driver in 36 cohorts (Act 3, LoF 33); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18037","ensembl":"ENSG00000189079","uniprot":"Q68CP9","entrez":"196528","biology":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. Location: Nucleus (UniProt). Locus 12q12 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.67 with skin cancer (MONDO_0002898)","Hepatocellular carcinoma: Open Targets association 0.63 with hepatocellular carcinoma (MONDO_0007256); CIViC evidence names this disease","Oesophageal cancer: Open Targets association 0.57 with oesophageal cancer (MONDO_0007576); IntOGen driver in 3 cohorts (ESCA, ESCC)","Gastric & gastro-oesophageal junction cancer: IntOGen driver in 2 cohorts (STAD)","Biliary tract cancer: Open Targets association 0.57 with biliary tract cancer (MONDO_0003060)","Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/arid2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"biliary-tract-cancer","kind":"cancer","name":"Biliary tract cancer (all types)","route":"/cancers/biliary-tract-cancer/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}