{"entity":{"id":"arid5b","kind":"target","name":"ARID5B","aka":["AT-rich interaction domain 5B","AT-rich interactive domain-containing protein 5B","FLJ21150","MRF2"],"tldr":"ARID5B (AT-rich interactive domain-containing protein 5B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.","summary":"Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver.\n\nOpen Targets scores its association with cancer at 0.43 (direct and indirect evidence; datatypes literature 0.26, animal model 0.53, genetic association 0.53).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17362","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17362"},{"label":"UniProt Q14865","url":"https://www.uniprot.org/uniprotkb/Q14865/entry"},{"label":"NCBI Gene 84159","url":"https://www.ncbi.nlm.nih.gov/gene/84159"},{"label":"Ensembl ENSG00000150347","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000150347"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","non-hodgkin-lymphoma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARID5B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:17362","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17362","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14865","url":"https://www.uniprot.org/uniprotkb/Q14865/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000150347","url":"https://platform.opentargets.org/target/ENSG00000150347/associations","note":"association with cancer (MONDO_0004992) 0.43; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.60, non-Hodgkin lymphoma 0.60, leukaemia 0.60 (GraphQL API, CC0)"}],"hgnc":"HGNC:17362","ensembl":"ENSG00000150347","uniprot":"Q14865","entrez":"84159","biology":"Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. Location: Nucleus (UniProt). Locus 10q21.2 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908)","Acute lymphoblastic leukaemia: Open Targets association 0.60 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/arid5b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}