{"entity":{"id":"arrb1","kind":"target","name":"ARRB1","aka":["arrestin beta 1","Beta-arrestin-1","ARR1"],"tldr":"ARRB1 (Beta-arrestin-1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signalling by mediating both receptor desensitisation and resensitisation processes. During homologous desensitisation, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalisation by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs).\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.97, animal model 0.48, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:711","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:711"},{"label":"UniProt P49407","url":"https://www.uniprot.org/uniprotkb/P49407/entry"},{"label":"NCBI Gene 408","url":"https://www.ncbi.nlm.nih.gov/gene/408"},{"label":"Ensembl ENSG00000137486","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137486"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARRB1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:711","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:711","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P49407","url":"https://www.uniprot.org/uniprotkb/P49407/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000137486","url":"https://platform.opentargets.org/target/ENSG00000137486/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:711","ensembl":"ENSG00000137486","uniprot":"P49407","entrez":"408","biology":"Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signalling by mediating both receptor desensitisation and resensitisation processes. During homologous desensitisation, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalisation by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalised arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G proteins. Two different modes of arrestin-mediated internalisation occur. Location: Cytoplasm; Nucleus; Cell membrane; Membrane, clathrin-coated pit (UniProt). Locus 11q13.4 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/arrb1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}