{"entity":{"id":"ast-3424","kind":"drug","name":"AST-3424","aka":["OBI-3424","TH-3424"],"tldr":"AST-3424 is an experimental small molecule AKR1C3-activated prodrug from Ascentawits Pharmaceuticals, in phase 2 trials for hepatocellular carcinoma, advanced solid tumours and T-cell acute lymphoblastic leukaemia and other cancers.","summary":"AST-3424 (OBI-3424, TH-3424) is a small molecule AKR1C3-activated prodrug (DNA alkylator) from Ascentawits Pharmaceuticals, with OBI Pharma as partner and Zhejiang Hisun Pharmaceutical as partner. A nitrogen mustard prodrug that the enzyme AKR1C3 cleaves to an active molecule that alkylates and cross-links DNA, so it is aimed at tumours with high AKR1C3. Its furthest stage is phase 2, for hepatocellular carcinoma, advanced solid tumours, T-cell acute lymphoblastic leukaemia and T-cell lymphoblastic lymphoma. ClinicalTrials.gov registers it in 4 studies linked below. Registry: NCT07310173 phase 2b vs regorafenib in AKR1C3-high HCC, recruiting (sponsor Zhejiang Hisun); NCT06239155 phase 1/2 active, not recruiting (sponsor Ascentawits); NCT04315324 phase 1/2 in T-ALL/T-LBL (SWOG/NCI) active, not recruiting; OBI Pharma's NCT03592264 phase 1/2 terminated. Whether it works in people has not been established unless a trial below reports it.","status":"phase-2","asOf":"2026-11-03","links":[{"label":"Ascentawits Pharmaceuticals: pmc.ncbi.nlm.nih.gov","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8332853/"},{"label":"Ascentawits Pharmaceuticals: pmc.ncbi.nlm.nih.gov","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8332853/"},{"label":"Ascentawits Pharmaceuticals: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT04315324"},{"label":"ClinicalTrials.gov: trials of AST-3424","url":"https://clinicaltrials.gov/search?intr=AST-3424"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["hcc","metastatic-cancer","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["ascentawits-pharmaceuticals","obi-pharma","zhejiang-hisun"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06239155","nct07310173","nct04315324","nct03592264"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"AST-3424","modality":"Small molecule AKR1C3-activated prodrug (DNA alkylator)","mechanism":"A nitrogen mustard prodrug that the enzyme AKR1C3 cleaves to an active molecule that alkylates and cross-links DNA, so it is aimed at tumours with high AKR1C3.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ast-3424/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"ascentawits-pharmaceuticals","kind":"company","name":"Ascentawits Pharmaceuticals","route":"/companies/ascentawits-pharmaceuticals/"},{"id":"obi-pharma","kind":"company","name":"OBI Pharma","route":"/companies/obi-pharma/"},{"id":"zhejiang-hisun","kind":"company","name":"Zhejiang Hisun Pharmaceutical","route":"/companies/zhejiang-hisun/"}],"trial":[{"id":"nct06239155","kind":"trial","name":"A Phase I/II Study of AST-3424 in Subjects With Advanced Solid Tumors","route":"/trials/nct06239155/"},{"id":"nct03592264","kind":"trial","name":"A Phase I/II Study of OBI-3424 in Subjects with Advanced Solid Tumors","route":"/trials/nct03592264/"},{"id":"nct07310173","kind":"trial","name":"Phase IIb Study of AST-3424 in Patients With AKR1C3-high Expressing Advanced Hepatocellular Carcinoma","route":"/trials/nct07310173/"},{"id":"nct04315324","kind":"trial","name":"Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)","route":"/trials/nct04315324/"}],"target":[{"id":"akr1c3","kind":"target","name":"AKR1C3","route":"/targets/akr1c3/"}]}}