{"entity":{"id":"atf1","kind":"target","name":"ATF1","aka":["activating transcription factor 1","Cyclic AMP-dependent transcription factor ATF-1","TREB36"],"tldr":"ATF1 (Cyclic AMP-dependent transcription factor ATF-1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas, Colorectal cancer and Melanoma.","summary":"This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.52, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:783","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:783"},{"label":"UniProt P18846","url":"https://www.uniprot.org/uniprotkb/P18846/entry"},{"label":"NCBI Gene 466","url":"https://www.ncbi.nlm.nih.gov/gene/466"},{"label":"Ensembl ENSG00000123268","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000123268"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["sarcoma","colorectal","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ATF1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:783","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:783","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P18846","url":"https://www.uniprot.org/uniprotkb/P18846/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000123268","url":"https://platform.opentargets.org/target/ENSG00000123268/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: colorectal cancer 0.51, melanoma 0.54, sarcoma 0.59 (GraphQL API, CC0)"}],"hgnc":"HGNC:783","ensembl":"ENSG00000123268","uniprot":"P18846","entrez":"466","biology":"This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. Location: Nucleus (UniProt). Locus 12q13.12 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089)","Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)","Melanoma: Open Targets association 0.54 with melanoma (MONDO_0005105)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/atf1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}