{"entity":{"id":"atf7ip","kind":"target","name":"ATF7IP","aka":["activating transcription factor 7 interacting protein","Activating transcription factor 7-interacting protein 1","FLJ10688","p621","ATF7IP1","MCAF1"],"tldr":"ATF7IP (Activating transcription factor 7-interacting protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer and Non-small-cell lung cancer.","summary":"Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.61, somatic mutation 0.54). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Lung Adenocarcinoma, Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20092","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20092"},{"label":"UniProt Q6VMQ6","url":"https://www.uniprot.org/uniprotkb/Q6VMQ6/entry"},{"label":"NCBI Gene 55729","url":"https://www.ncbi.nlm.nih.gov/gene/55729"},{"label":"Ensembl ENSG00000171681","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171681"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["endometrial","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ATF7IP","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:20092","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20092","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6VMQ6","url":"https://www.uniprot.org/uniprotkb/Q6VMQ6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000171681","url":"https://platform.opentargets.org/target/ENSG00000171681/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"},{"label":"IntOGen ATF7IP","url":"https://www.intogen.org/search?gene=ATF7IP","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:20092","ensembl":"ENSG00000171681","uniprot":"Q6VMQ6","entrez":"55729","biology":"Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilises SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Location: Nucleus (UniProt). Locus 12p13.1 (HGNC).","whereFound":["Endometrial cancer: IntOGen driver in 1 cohort (UCEC)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/atf7ip/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}