{"entity":{"id":"atg12","kind":"target","name":"ATG12","aka":["autophagy related 12","Ubiquitin-like protein ATG12","APG12","APG12L"],"tldr":"ATG12 (Ubiquitin-like protein ATG12) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.","summary":"Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:588","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:588"},{"label":"UniProt O94817","url":"https://www.uniprot.org/uniprotkb/O94817/entry"},{"label":"NCBI Gene 9140","url":"https://www.ncbi.nlm.nih.gov/gene/9140"},{"label":"Ensembl ENSG00000145782","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145782"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ATG12","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:588","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:588","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O94817","url":"https://www.uniprot.org/uniprotkb/O94817/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ATG12","url":"https://civicdb.org/features/7227","note":"1 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Ductal Adenocarcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:588","ensembl":"ENSG00000145782","uniprot":"O94817","entrez":"9140","biology":"Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. As part of the ATG8 conjugation system with ATG5 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established. Location: Cytoplasm; Preautophagosomal structure membrane (UniProt). Locus 5q22.3 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/atg12/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}