{"entity":{"id":"atic","kind":"target","name":"ATIC","aka":["5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase","Bifunctional purine biosynthesis protein ATIC","AICARFT","IMPCHASE"],"tldr":"ATIC (Bifunctional purine biosynthesis protein ATIC) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.","summary":"Bifunctional enzyme that catalyses the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.93, genetic association 0.00, somatic mutation 0.90).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:794","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:794"},{"label":"UniProt P31939","url":"https://www.uniprot.org/uniprotkb/P31939/entry"},{"label":"NCBI Gene 471","url":"https://www.ncbi.nlm.nih.gov/gene/471"},{"label":"Ensembl ENSG00000138363","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138363"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ATIC","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:794","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:794","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31939","url":"https://www.uniprot.org/uniprotkb/P31939/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000138363","url":"https://platform.opentargets.org/target/ENSG00000138363/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: lung cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:794","ensembl":"ENSG00000138363","uniprot":"P31939","entrez":"471","biology":"Bifunctional enzyme that catalyses the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyses the cyclisation of FAICAR to inosine monophosphate (IMP). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukaemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalisation. Location: Cytoplasm, cytosol (UniProt). Locus 2q35 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/atic/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"}]}}