{"entity":{"id":"atp7b","kind":"target","name":"ATP7B","aka":["ATPase copper transporting beta","Copper-transporting ATPase 2"],"tldr":"ATP7B (Copper-transporting ATPase 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.","summary":"Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.\n\nCIViC holds 4 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin, Tranilast, Telmisartan and Amphotericin B.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:870","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:870"},{"label":"UniProt P35670","url":"https://www.uniprot.org/uniprotkb/P35670/entry"},{"label":"NCBI Gene 540","url":"https://www.ncbi.nlm.nih.gov/gene/540"},{"label":"Ensembl ENSG00000123191","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000123191"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ATP7B","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:870","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:870","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35670","url":"https://www.uniprot.org/uniprotkb/P35670/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ATP7B","url":"https://civicdb.org/features/519","note":"4 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:870","ensembl":"ENSG00000123191","uniprot":"P35670","entrez":"540","biology":"Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. Location: Golgi apparatus, trans-Golgi network membrane; Late endosome; Golgi apparatus membrane; Cytoplasm (UniProt). Locus 13q14.3 (HGNC).","whereFound":["Ovarian cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/atp7b/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}