{"entity":{"id":"aurkb","kind":"target","name":"AURKB","aka":["aurora kinase B","Aurora kinase B","Aik2","IPL1","AurB","AIM-1","ARK2","STK5","PPP1R48","STK12"],"tldr":"AURKB (Aurora kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.","summary":"Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Alisertib, Barasertib and Copanlisib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11390","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11390"},{"label":"UniProt Q96GD4","url":"https://www.uniprot.org/uniprotkb/Q96GD4/entry"},{"label":"NCBI Gene 9212","url":"https://www.ncbi.nlm.nih.gov/gene/9212"},{"label":"Ensembl ENSG00000178999","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178999"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AURKB","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11390","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11390","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96GD4","url":"https://www.uniprot.org/uniprotkb/Q96GD4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene AURKB","url":"https://civicdb.org/features/7282","note":"1 evidence items, 0 assertions, 1 variants; diseases: Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:11390","ensembl":"ENSG00000178999","uniprot":"Q96GD4","entrez":"9212","biology":"Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signalling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Location: Nucleus; Chromosome; Chromosome, centromere; Chromosome, centromere, kinetochore (UniProt). Locus 17p13.1 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: CIViC evidence names this disease"],"targetClass":"kinase","prevalence":[]},"route":"/targets/aurkb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}]}}