{"entity":{"id":"avl-102","kind":"drug","name":"AVL-102","aka":[],"tldr":"AVL-102 is an experimental mRNA therapeutic HPV vaccine from Beijing Xunsheng Biomedical Research, in preclinical development for high-grade intraepithelial lesions associated with HPV16/18/52/58.","summary":"AVL-102 is a mRNA therapeutic HPV vaccine from Beijing Xunsheng Biomedical Research, with Beijing Anweituo Biomedicine Co., Ltd. as partner. An mRNA vaccine meant to induce cellular immune responses against HPV antigens and clear HPV-infected abnormal cells. Its furthest stage is preclinical development, for high-grade intraepithelial lesions (cervix, anus, vagina, vulva) associated with HPV16/18/52/58 (precancer). No clinical trial naming it is registered on ClinicalTrials.gov. Implied IND approval (默示许可) from China's CDE on 14 August 2026, per company news; no trial start reported. It has not been shown to work in people.","status":"preclinical","asOf":"2026-11-03","links":[{"label":"Beijing Xunsheng Biomedical Research: aeonvital.com","url":"http://www.aeonvital.com/wzxq?article_id=104"},{"label":"Beijing Xunsheng Biomedical Research: aeonvital.com","url":"http://www.aeonvital.com/wzxq?article_id=104"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["beijing-xunsheng-biomedical"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"AVL-102","modality":"mRNA therapeutic HPV vaccine","mechanism":"An mRNA vaccine meant to induce cellular immune responses against HPV antigens and clear HPV-infected abnormal cells.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/avl-102/","neighbours":{"company":[{"id":"beijing-xunsheng-biomedical","kind":"company","name":"Beijing Xunsheng Biomedical Research","route":"/companies/beijing-xunsheng-biomedical/"}]}}