{"entity":{"id":"avzo-023","kind":"drug","name":"AVZO-023","aka":[],"tldr":"AVZO-023 is a small-molecule inhibitor from Avenzo Therapeutics, Inc., in registered phase 2 trials for metastatic cancer.","summary":"AVZO-023 is listed on ClinicalTrials.gov as an intervention in 1 registered phase 2 trial sponsored by Avenzo Therapeutics, Inc., in metastatic cancer. Described in the registry record as a avzo-023 is an oral selective cdk4 inhibitor; the trial entries below carry the sponsor's wording. OnCo records the agent from the registry alone; approvals, results and the sponsor's own description will follow as they are published.","status":"phase-2","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov: trials of AVZO-023","url":"https://clinicaltrials.gov/search?intr=AVZO-023"}],"tags":["pipeline","ctgov-ingest","registry-only"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["cdk4-6"],"drugs":[],"companies":["avenzo"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06998407"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2, registry-only)","editedOn":"2026-09-16"},"code":"AVZO-023","modality":"Small-molecule inhibitor","mechanism":"Described in the registry record as a avzo-023 is an oral selective cdk4 inhibitor; the trial entries below carry the sponsor's wording.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/avzo-023/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"cdk4-6","kind":"target","name":"CDK4/6","route":"/targets/cdk4-6/"}],"company":[{"id":"avenzo","kind":"company","name":"Avenzo Therapeutics","route":"/companies/avenzo/"}],"trial":[{"id":"nct06998407","kind":"trial","name":"ORION-1: Study of AVZO-023 as a Single Agent and in Combination With AVZO-021, and/or Endocrine Therapy in Advanced Solid Tumors","route":"/trials/nct06998407/"}]}}