{"entity":{"id":"avzo-103","kind":"drug","name":"AVZO-103","aka":[],"tldr":"AVZO-103 is an experimental antibody-drug conjugate being studied in people with advanced cancer. Its benefit and safety are still being evaluated.","summary":"ASCO GU 2026 trial-in-progress abstract TPS908 describes AVZO-103-1001 (BEACON-1), a phase 1/2 study of monotherapy and combinations in advanced urothelial and other solid tumors. The design includes dose escalation followed by expansion. Its rationale and xenograft activity do not constitute patient efficacy results. Trial participation and prior ADC rules depend on the specific cohort.","status":"phase-1","asOf":"2026-10-06","links":[{"label":"Publisher abstract","url":"https://doi.org/10.1200/jco.2026.44.7_suppl.tps908"},{"label":"ClinicalTrials.gov NCT07193511","url":"https://clinicaltrials.gov/study/NCT07193511"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["adc","bispecific-adc"],"targets":["trop2","nectin4"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct07193511"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"modality":"ADC","payload":"Exatecan (TOP1 inhibitor)","mechanism":"Bispecific Nectin-4/TROP2 ADC delivering an exatecan payload.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/avzo-103/","neighbours":{"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"},{"id":"bispecific-adc","kind":"technology","name":"Bispecific ADC","route":"/technologies/bispecific-adc/"}],"target":[{"id":"nectin4","kind":"target","name":"Nectin-4","route":"/targets/nectin4/"},{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}],"trial":[{"id":"nct07193511","kind":"trial","name":"BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)","route":"/trials/nct07193511/"}]}}