{"entity":{"id":"axin2","kind":"target","name":"AXIN2","aka":["axin 2","Axin-2","MGC126582","DKFZp781B0869"],"tldr":"AXIN2 (Axin-2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Skin cancer, Lung cancer and 2 more.","summary":"Inhibitor of the Wnt signalling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Vemurafenib and Cobimetinib. Open Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.96, genetic association 0.87, somatic mutation 0.92, animal model 0.38).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:904","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:904"},{"label":"UniProt Q9Y2T1","url":"https://www.uniprot.org/uniprotkb/Q9Y2T1/entry"},{"label":"NCBI Gene 8313","url":"https://www.ncbi.nlm.nih.gov/gene/8313"},{"label":"Ensembl ENSG00000168646","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168646"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["colorectal","skin-cancer","lung-cancer","neuroendocrine","cll"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Ganglioglioma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AXIN2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:904","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:904","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y2T1","url":"https://www.uniprot.org/uniprotkb/Q9Y2T1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene AXIN2","url":"https://civicdb.org/features/6572","note":"2 evidence items, 0 assertions, 2 variants; diseases: Chronic Lymphocytic Leukaemia, Ganglioglioma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000168646","url":"https://platform.opentargets.org/target/ENSG00000168646/associations","note":"association with cancer (MONDO_0004992) 0.80; per-cancer scores at or above 0.5: colorectal cancer 0.73, neuroendocrine neoplasm 0.51, skin cancer 0.54, lung cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:904","ensembl":"ENSG00000168646","uniprot":"Q9Y2T1","entrez":"8313","biology":"Inhibitor of the Wnt signalling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. Location: Cytoplasm (UniProt). Locus 17q24.1 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.73 with colorectal cancer (MONDO_0005575)","Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)","Neuroendocrine tumours: Open Targets association 0.51 with neuroendocrine neoplasm (MONDO_0019496)","Chronic lymphocytic leukaemia: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/axin2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}