{"entity":{"id":"b4galt1","kind":"target","name":"B4GALT1","aka":["beta-1,4-galactosyltransferase 1","Beta-1,4-galactosyltransferase 1","beta4Gal-T1","GGTB2"],"tldr":"B4GALT1 (Beta-1,4-galactosyltransferase 1) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma.","summary":"Galactosyltransferase acting in the Golgi stacks. Catalyses the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans. Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:924","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:924"},{"label":"UniProt P15291","url":"https://www.uniprot.org/uniprotkb/P15291/entry"},{"label":"NCBI Gene 2683","url":"https://www.ncbi.nlm.nih.gov/gene/2683"},{"label":"Ensembl ENSG00000086062","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000086062"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"B4GALT1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:924","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:924","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P15291","url":"https://www.uniprot.org/uniprotkb/P15291/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene B4GALT1","url":"https://civicdb.org/features/2239","note":"1 evidence items, 0 assertions, 1 variants; diseases: Renal Cell Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:924","ensembl":"ENSG00000086062","uniprot":"P15291","entrez":"2683","biology":"Galactosyltransferase acting in the Golgi stacks. Catalyses the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans. Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms. Galactosylates complex-type N-glycans attached on the fragment crystallizable (Fc) of immunoglobulin-gamma isotypes (IgGs), a prerequisite for antibody glycan sialylation and related anti-inflammatory effector functions. Can also transfer a Gal residue to free GlcNAc to form N-acetyllactosamine. With LALBA/alpha-lactalbumin forms the lactose synthase complex responsible for production of large amounts of lactose in the lactating mammary gland. Location: Golgi apparatus, Golgi stack membrane; Cell membrane; Cell surface; Cell projection, filopodium (UniProt). Locus 9p21.1 (HGNC).","whereFound":["Renal cell carcinoma: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/b4galt1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}