{"entity":{"id":"bag4","kind":"target","name":"BAG4","aka":["BAG cochaperone 4","BAG family molecular chaperone regulator 4"],"tldr":"BAG4 (BAG family molecular chaperone regulator 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signalling. Negative regulator of PRKN translocation to damaged mitochondria.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.88, affected pathway 0.95, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:940","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:940"},{"label":"UniProt O95429","url":"https://www.uniprot.org/uniprotkb/O95429/entry"},{"label":"NCBI Gene 9530","url":"https://www.ncbi.nlm.nih.gov/gene/9530"},{"label":"Ensembl ENSG00000156735","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156735"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BAG4","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:940","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:940","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95429","url":"https://www.uniprot.org/uniprotkb/O95429/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000156735","url":"https://platform.opentargets.org/target/ENSG00000156735/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"hgnc":"HGNC:940","ensembl":"ENSG00000156735","uniprot":"O95429","entrez":"9530","biology":"Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signalling. Negative regulator of PRKN translocation to damaged mitochondria. Location: Cytoplasm (UniProt). Locus 8p11.23 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/bag4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}