{"entity":{"id":"bak1","kind":"target","name":"BAK1","aka":["BCL2 antagonist/killer 1","Bcl-2 homologous antagonist/killer","BCL2L7","CDN1"],"tldr":"BAK1 (Bcl-2 homologous antagonist/killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.","summary":"Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilisation by oligomerising to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.\n\nOpen Targets scores its association with cancer at 0.48 (direct and indirect evidence; datatypes literature 0.97, animal model 0.43, genetic association 0.59).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:949","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:949"},{"label":"UniProt Q16611","url":"https://www.uniprot.org/uniprotkb/Q16611/entry"},{"label":"NCBI Gene 578","url":"https://www.ncbi.nlm.nih.gov/gene/578"},{"label":"Ensembl ENSG00000030110","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000030110"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","non-hodgkin-lymphoma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BAK1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:949","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:949","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q16611","url":"https://www.uniprot.org/uniprotkb/Q16611/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000030110","url":"https://platform.opentargets.org/target/ENSG00000030110/associations","note":"association with cancer (MONDO_0004992) 0.48; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.51, non-Hodgkin lymphoma 0.51, leukaemia 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:949","ensembl":"ENSG00000030110","uniprot":"Q16611","entrez":"578","biology":"Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilisation by oligomerising to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. Location: Mitochondrion outer membrane (UniProt). Locus 6p21.31 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)","Acute lymphoblastic leukaemia: Open Targets association 0.51 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"other","prevalence":[]},"route":"/targets/bak1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}