{"entity":{"id":"baz1a","kind":"target","name":"BAZ1A","aka":["bromodomain adjacent to zinc finger domain 1A","Bromodomain adjacent to zinc finger domain protein 1A","hACF1","ACF1","WALp1","WCRF180"],"tldr":"BAZ1A (Bromodomain adjacent to zinc finger domain protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Small-cell lung cancer.","summary":"Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and centre-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the centre of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex.\n\nOpen Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.59, genetic association 0.51, somatic mutation 0.49). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Small Cell Lung Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:960","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:960"},{"label":"UniProt Q9NRL2","url":"https://www.uniprot.org/uniprotkb/Q9NRL2/entry"},{"label":"NCBI Gene 11177","url":"https://www.ncbi.nlm.nih.gov/gene/11177"},{"label":"Ensembl ENSG00000198604","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198604"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["sclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BAZ1A","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:960","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:960","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NRL2","url":"https://www.uniprot.org/uniprotkb/Q9NRL2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000198604","url":"https://platform.opentargets.org/target/ENSG00000198604/associations","note":"association with cancer (MONDO_0004992) 0.50;  (GraphQL API, CC0)"},{"label":"IntOGen BAZ1A","url":"https://www.intogen.org/search?gene=BAZ1A","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:960","ensembl":"ENSG00000198604","uniprot":"Q9NRL2","entrez":"11177","biology":"Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and centre-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the centre of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression. Location: Nucleus (UniProt). Locus 14q13.1-q13.2 (HGNC).","whereFound":["Small-cell lung cancer: IntOGen driver in 1 cohort (SCLC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/baz1a/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}]}}