{"entity":{"id":"bcb-214","kind":"drug","name":"BCB-214","aka":[],"tldr":"BCB-214 is an experimental CAR T cell therapy from BrainChild Bio, at a stage the company does not state for glioblastoma and diffuse midline glioma.","summary":"BCB-214 is a CAR T cell therapy (triple-targeting) from BrainChild Bio. A triple-targeting CAR T cell therapy against EGFR, B7-H3 and IL13Ralpha2, combined with the company's functional retention technologies and repeated intracerebroventricular dosing, designed to overcome tumour heterogeneity and the immunosuppressive tumour microenvironment. The company does not state its stage; it is aimed at glioblastoma and diffuse midline glioma. No clinical trial naming it is registered on ClinicalTrials.gov. The pipeline page gives no stage; no ClinicalTrials.gov study names BCB-214 (query.intr=BCB-214 returned 0 on 3 Nov 2026). It has not been shown to work in people.","asOf":"2026-11-03","links":[{"label":"BrainChild Bio: brainchildbio.com","url":"https://www.brainchildbio.com/pipeline"},{"label":"BrainChild Bio: brainchildbio.com","url":"https://www.brainchildbio.com/pipeline"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":["egfr","b7h3"],"drugs":[],"companies":["brainchild-bio"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"BCB-214","modality":"CAR T cell therapy (triple-targeting)","mechanism":"A triple-targeting CAR T cell therapy against EGFR, B7-H3 and IL13Ralpha2, combined with the company's functional retention technologies and repeated intracerebroventricular dosing, designed to overcome tumour heterogeneity and the immunosuppressive tumour microenvironment.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/bcb-214/","neighbours":{"target":[{"id":"b7h3","kind":"target","name":"B7-H3","route":"/targets/b7h3/"},{"id":"egfr","kind":"target","name":"EGFR","route":"/targets/egfr/"}],"company":[{"id":"brainchild-bio","kind":"company","name":"BrainChild Bio","route":"/companies/brainchild-bio/"}]}}