{"entity":{"id":"bcl3","kind":"target","name":"BCL3","aka":["BCL3 transcription coactivator","B-cell lymphoma 3 protein","D19S37","BCL4"],"tldr":"BCL3 (B-cell lymphoma 3 protein) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, animal model 0.53, genetic association 0.00, somatic mutation 0.95).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:998","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:998"},{"label":"UniProt P20749","url":"https://www.uniprot.org/uniprotkb/P20749/entry"},{"label":"NCBI Gene 602","url":"https://www.ncbi.nlm.nih.gov/gene/602"},{"label":"Ensembl ENSG00000069399","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000069399"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BCL3","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:998","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:998","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P20749","url":"https://www.uniprot.org/uniprotkb/P20749/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000069399","url":"https://platform.opentargets.org/target/ENSG00000069399/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:998","ensembl":"ENSG00000069399","uniprot":"P20749","entrez":"602","biology":"Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. Location: Nucleus; Cytoplasm; Cytoplasm, perinuclear region (UniProt). Locus 19q13.32 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/bcl3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}