{"entity":{"id":"bcl9l","kind":"target","name":"BCL9L","aka":["BCL9 like","B-cell CLL/lymphoma 9-like protein","DLNB11","B9L","Bcl9-2"],"tldr":"BCL9L (B-cell CLL/lymphoma 9-like protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Skin cancer, Gastric & gastro-oesophageal junction cancer and 1 more.","summary":"Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis.\n\nOpen Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.94). IntOGen calls it a driver in 4 cohorts (0 activating, 4 loss-of-function), covering Colon Adenocarcinoma, Colorectal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23688","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23688"},{"label":"UniProt Q86UU0","url":"https://www.uniprot.org/uniprotkb/Q86UU0/entry"},{"label":"NCBI Gene 283149","url":"https://www.ncbi.nlm.nih.gov/gene/283149"},{"label":"Ensembl ENSG00000186174","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186174"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["colorectal","skin-cancer","gastric","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BCL9L","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:23688","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23688","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86UU0","url":"https://www.uniprot.org/uniprotkb/Q86UU0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000186174","url":"https://platform.opentargets.org/target/ENSG00000186174/associations","note":"association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: colorectal cancer 0.66, gastric cancer 0.52, melanoma 0.56, skin cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen BCL9L","url":"https://www.intogen.org/search?gene=BCL9L","note":"driver in 4 cohorts (Act 0, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:23688","ensembl":"ENSG00000186174","uniprot":"Q86UU0","entrez":"283149","biology":"Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1. Location: Nucleus (UniProt). Locus 11q23.3 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.66 with colorectal cancer (MONDO_0005575); IntOGen driver in 4 cohorts (COAD, COADREAD)","Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)","Melanoma: Open Targets association 0.56 with melanoma (MONDO_0005105)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/bcl9l/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}