{"entity":{"id":"bclaf1","kind":"target","name":"BCLAF1","aka":["BCL2 associated transcription factor 1","Bcl-2-associated transcription factor 1","KIAA0164"],"tldr":"BCLAF1 (Bcl-2-associated transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Gastric & gastro-oesophageal junction cancer, Acute myeloid leukaemia and 2 more.","summary":"Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.\n\nIntOGen calls it a driver in 5 cohorts (4 activating, 1 loss-of-function), covering Acute Myeloid Leukaemia, Melanoma, Prostate Adenocarcinoma, Stomach Adenocarcinoma, Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16863","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16863"},{"label":"UniProt Q9NYF8","url":"https://www.uniprot.org/uniprotkb/Q9NYF8/entry"},{"label":"NCBI Gene 9774","url":"https://www.ncbi.nlm.nih.gov/gene/9774"},{"label":"Ensembl ENSG00000029363","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000029363"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["prostate","gastric","aml","melanoma","uterine-carcinosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BCLAF1","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:16863","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16863","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NYF8","url":"https://www.uniprot.org/uniprotkb/Q9NYF8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen BCLAF1","url":"https://www.intogen.org/search?gene=BCLAF1","note":"driver in 5 cohorts (Act 4, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:16863","ensembl":"ENSG00000029363","uniprot":"Q9NYF8","entrez":"9774","biology":"Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Location: Cytoplasm; Nucleus; Nucleus speckle; Nucleus, nucleoplasm (UniProt). Locus 6q23.3 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)","Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)","Melanoma: IntOGen driver in 1 cohort (MEL)","Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/bclaf1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"uterine-carcinosarcoma","kind":"cancer","name":"Uterine carcinosarcoma","route":"/cancers/uterine-carcinosarcoma/"}]}}