{"entity":{"id":"bcorl1","kind":"target","name":"BCORL1","aka":["BCL6 corepressor like 1","BCL-6 corepressor-like protein 1","FLJ11362","BCoR-L1","CXorf10"],"tldr":"BCORL1 (BCL-6 corepressor-like protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Pancreatic ductal adenocarcinoma, Skin cancer and 4 more.","summary":"Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.\n\nOpen Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.81, animal model 0.40, genetic association 0.00, somatic mutation 0.90). IntOGen calls it a driver in 6 cohorts (0 activating, 6 loss-of-function), covering Acute Myeloid Leukaemia, Colorectal Adenocarcinoma, High-Grade Glioma, NOS, Neuroblastoma, Pancreatic Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25657","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25657"},{"label":"UniProt Q5H9F3","url":"https://www.uniprot.org/uniprotkb/Q5H9F3/entry"},{"label":"NCBI Gene 63035","url":"https://www.ncbi.nlm.nih.gov/gene/63035"},{"label":"Ensembl ENSG00000085185","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085185"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["colorectal","pancreatic","skin-cancer","breast-cancer","neuroblastoma","aml","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 6 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: High-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BCORL1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:25657","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25657","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q5H9F3","url":"https://www.uniprot.org/uniprotkb/Q5H9F3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000085185","url":"https://platform.opentargets.org/target/ENSG00000085185/associations","note":"association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: colorectal cancer 0.60, melanoma 0.52, skin cancer 0.55, breast cancer 0.54 (GraphQL API, CC0)"},{"label":"IntOGen BCORL1","url":"https://www.intogen.org/search?gene=BCORL1","note":"driver in 6 cohorts (Act 0, LoF 6); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:25657","ensembl":"ENSG00000085185","uniprot":"Q5H9F3","entrez":"63035","biology":"Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Location: Nucleus (UniProt). Locus Xq26.1 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.60 with colorectal cancer (MONDO_0005575); IntOGen driver in 1 cohort (COADREAD)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Neuroblastoma: IntOGen driver in 2 cohorts (NBL)","Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/bcorl1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}