{"entity":{"id":"birc6","kind":"target","name":"BIRC6","aka":["baculoviral IAP repeat containing 6","Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6","BRUCE"],"tldr":"BIRC6 (Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Breast cancer, Renal cell carcinoma and 5 more.","summary":"Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase. Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.83, genetic association 0.19, somatic mutation 0.55). IntOGen calls it a driver in 21 cohorts (6 activating, 14 loss-of-function), covering Anal Squamous Cell Carcinoma, Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Renal Clear Cell Carcinoma, Cholangiocarcinoma, Colorectal Adenocarcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13516","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13516"},{"label":"UniProt Q9NR09","url":"https://www.uniprot.org/uniprotkb/Q9NR09/entry"},{"label":"NCBI Gene 57448","url":"https://www.ncbi.nlm.nih.gov/gene/57448"},{"label":"Ensembl ENSG00000115760","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115760"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["urothelial","breast-cancer","rcc","endometrial","anal","colorectal","hcc","head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 6 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 14 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BIRC6","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:13516","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13516","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NR09","url":"https://www.uniprot.org/uniprotkb/Q9NR09/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene BIRC6","url":"https://civicdb.org/features/13783","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000115760","url":"https://platform.opentargets.org/target/ENSG00000115760/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"},{"label":"IntOGen BIRC6","url":"https://www.intogen.org/search?gene=BIRC6","note":"driver in 21 cohorts (Act 6, LoF 14); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:13516","ensembl":"ENSG00000115760","uniprot":"Q9NR09","entrez":"57448","biology":"Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase. Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide. Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6. Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent. Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2. Location: Golgi apparatus, trans-Golgi network membrane; Endosome; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 2p22.3 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 3 cohorts (BLCA)","Breast cancer: IntOGen driver in 2 cohorts (BRCA)","Renal cell carcinoma: IntOGen driver in 2 cohorts (CCRCC)","Endometrial cancer: IntOGen driver in 2 cohorts (UCEC)","Anal cancer: IntOGen driver in 1 cohort (ANSC)","Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/birc6/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"anal","kind":"cancer","name":"Anal cancer (squamous cell carcinoma)","route":"/cancers/anal/"},{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}