{"entity":{"id":"bmp6","kind":"target","name":"BMP6","aka":["bone morphogenetic protein 6","Bone morphogenetic protein 6","VGR1"],"tldr":"BMP6 (Bone morphogenetic protein 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.","summary":"Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for haemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1073","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1073"},{"label":"UniProt P22004","url":"https://www.uniprot.org/uniprotkb/P22004/entry"},{"label":"NCBI Gene 654","url":"https://www.ncbi.nlm.nih.gov/gene/654"},{"label":"Ensembl ENSG00000153162","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153162"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BMP6","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:1073","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1073","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P22004","url":"https://www.uniprot.org/uniprotkb/P22004/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen BMP6","url":"https://www.intogen.org/search?gene=BMP6","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:1073","ensembl":"ENSG00000153162","uniprot":"P22004","entrez":"654","biology":"Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for haemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signalling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signalling cascade to modulate VEGF signalling by regulating VEGFR2 expression. Location: Secreted (UniProt). Locus 6p24.3 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 1 cohort (PRAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/bmp6/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}