{"entity":{"id":"bmp7","kind":"target","name":"BMP7","aka":["bone morphogenetic protein 7","Bone morphogenetic protein 7","OP-1"],"tldr":"BMP7 (Bone morphogenetic protein 7) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Burkitt lymphoma.","summary":"Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, haematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signalling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1074","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1074"},{"label":"UniProt P18075","url":"https://www.uniprot.org/uniprotkb/P18075/entry"},{"label":"NCBI Gene 655","url":"https://www.ncbi.nlm.nih.gov/gene/655"},{"label":"Ensembl ENSG00000101144","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101144"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["burkitt-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["tumor-dormancy"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BMP7","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:1074","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1074","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P18075","url":"https://www.uniprot.org/uniprotkb/P18075/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene BMP7","url":"https://civicdb.org/features/608","note":"1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)"}],"hgnc":"HGNC:1074","ensembl":"ENSG00000101144","uniprot":"P18075","entrez":"655","biology":"Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, haematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signalling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signalling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors. Location: Secreted (UniProt). Locus 20q13.31 (HGNC).","whereFound":["Burkitt lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/bmp7/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"}],"pathway":[{"id":"tumor-dormancy","kind":"pathway","name":"Tumour dormancy","route":"/pathways/tumor-dormancy/"}]}}