{"entity":{"id":"bnc2","kind":"target","name":"BNC2","aka":["basonuclin zinc finger protein 2","Zinc finger protein basonuclin-2","BSN2","FLJ20043","bn2"],"tldr":"BNC2 (Zinc finger protein basonuclin-2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.","summary":"Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.87, animal model 0.45, genetic association 0.71).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30988","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30988"},{"label":"UniProt Q6ZN30","url":"https://www.uniprot.org/uniprotkb/Q6ZN30/entry"},{"label":"NCBI Gene 54796","url":"https://www.ncbi.nlm.nih.gov/gene/54796"},{"label":"Ensembl ENSG00000173068","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000173068"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BNC2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:30988","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30988","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6ZN30","url":"https://www.uniprot.org/uniprotkb/Q6ZN30/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000173068","url":"https://platform.opentargets.org/target/ENSG00000173068/associations","note":"association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: skin cancer 0.52, basal cell carcinoma 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:30988","ensembl":"ENSG00000173068","uniprot":"Q6ZN30","entrez":"54796","biology":"Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development. Location: Nucleus (UniProt). Locus 9p22.3-p22.2 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Basal cell carcinoma: Open Targets association 0.53 with basal cell carcinoma (MONDO_0020804)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/bnc2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}