{"entity":{"id":"brd7","kind":"target","name":"BRD7","aka":["bromodomain containing 7","Bromodomain-containing protein 7","CELTIX1","BP75","SMARCI1"],"tldr":"BRD7 (Bromodomain-containing protein 7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Melanoma.","summary":"Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signalling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.73). IntOGen calls it a driver in 4 cohorts (0 activating, 4 loss-of-function), covering Hepatocellular Carcinoma, Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14310","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14310"},{"label":"UniProt Q9NPI1","url":"https://www.uniprot.org/uniprotkb/Q9NPI1/entry"},{"label":"NCBI Gene 29117","url":"https://www.ncbi.nlm.nih.gov/gene/29117"},{"label":"Ensembl ENSG00000166164","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166164"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["hcc","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BRD7","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:14310","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14310","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NPI1","url":"https://www.uniprot.org/uniprotkb/Q9NPI1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000166164","url":"https://platform.opentargets.org/target/ENSG00000166164/associations","note":"association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: hepatocellular carcinoma 0.51 (GraphQL API, CC0)"},{"label":"IntOGen BRD7","url":"https://www.intogen.org/search?gene=BRD7","note":"driver in 4 cohorts (Act 0, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:14310","ensembl":"ENSG00000166164","uniprot":"Q9NPI1","entrez":"29117","biology":"Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signalling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. Transcriptional corepressor that down-regulates the expression of target genes. Location: Nucleus; Chromosome (UniProt). Locus 16q12.1 (HGNC).","whereFound":["Hepatocellular carcinoma: Open Targets association 0.51 with hepatocellular carcinoma (MONDO_0007256); IntOGen driver in 3 cohorts (HCC)","Melanoma: IntOGen driver in 1 cohort (MEL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/brd7/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}