{"entity":{"id":"bria-ots","kind":"drug","name":"Bria-OTS","aka":[],"tldr":"Bria-OTS is a set of ready-made cell-based immunotherapies from BriaCell Therapeutics, matched to the patient. It is in an early trial in breast cancer, and prostate cancer is the next planned use.","summary":"Bria-OTS is a platform of personalised off-the-shelf cell-based immunotherapies from BriaCell Therapeutics, in a phase 1/2 study initially targeting breast cancer, according to the company, which plans to extend it to prostate cancer. NCI SBIR Phase II grant 5R44CA281555-03 funds BriaCell's work on an off-the-shelf tumour cell vaccine with HLA-matching alleles for advanced metastatic prostate cancer.","status":"phase-1","asOf":"2026-11-04","links":[{"label":"BriaCell Therapeutics","url":"https://briacell.com/"},{"label":"NIH RePORTER: award 5R44CA281555-03","url":"https://reporter.nih.gov/project-details/11398997"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":["immunotherapy"],"technologies":["shared-antigen-vaccine"],"targets":[],"drugs":[],"companies":["briacell"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors","editedOn":"2026-11-04"},"modality":"Off-the-shelf cell-based immunotherapy platform","mechanism":"Described by BriaCell Therapeutics as a platform of personalised off-the-shelf cell-based immunotherapies; its NCI award describes an off-the-shelf tumour cell vaccine carrying HLA-matching alleles.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/bria-ots/","neighbours":{"section":[{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"}],"technology":[{"id":"shared-antigen-vaccine","kind":"technology","name":"Off-the-shelf cancer vaccines","route":"/technologies/shared-antigen-vaccine/"}],"company":[{"id":"briacell","kind":"company","name":"BriaCell Therapeutics","route":"/companies/briacell/"}]}}