{"entity":{"id":"btm-3566","kind":"drug","name":"BTM-3566","aka":[],"tldr":"BTM-3566 is an experimental oral small molecule from Bantam Pharmaceutical, in phase 1 trials for relapsed or refractory mature B-cell lymphomas and advanced solid tumours.","summary":"BTM-3566 is an oral small molecule from Bantam Pharmaceutical. An oral small molecule that activates the mitochondrial protease OMA1, which cleaves OPA1 and DELE1 and switches on the integrated stress response, leading to apoptosis of tumour cells. Its furthest stage is phase 1, for relapsed or refractory mature B-cell lymphomas (initial focus DLBCL) and advanced solid tumours. ClinicalTrials.gov registers it in 2 studies linked below. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Bantam Pharmaceutical: bantampharma.com","url":"https://bantampharma.com/btm_3566/"},{"label":"Bantam Pharmaceutical: bantampharma.com","url":"https://bantampharma.com/"},{"label":"ClinicalTrials.gov: trials of BTM-3566","url":"https://clinicaltrials.gov/search?intr=BTM-3566"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["dlbcl","metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["bantam-pharmaceutical"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06792734","nct07266285"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"BTM-3566","modality":"Oral small molecule","mechanism":"An oral small molecule that activates the mitochondrial protease OMA1, which cleaves OPA1 and DELE1 and switches on the integrated stress response, leading to apoptosis of tumour cells.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/btm-3566/","neighbours":{"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"bantam-pharmaceutical","kind":"company","name":"Bantam Pharmaceutical","route":"/companies/bantam-pharmaceutical/"}],"trial":[{"id":"nct07266285","kind":"trial","name":"BTM-3566 in Advanced Solid Tumors","route":"/trials/nct07266285/"},{"id":"nct06792734","kind":"trial","name":"Phase 1 Trial of BTM-3566 in Relapsed/Refractory Mature B Cell Lymphomas","route":"/trials/nct06792734/"}]}}