{"entity":{"id":"bub1","kind":"target","name":"BUB1","aka":["BUB1 mitotic checkpoint serine/threonine kinase","hBUB1","BUB1L"],"tldr":"BUB1 is one of the kinases that stops a dividing cell pulling its chromosomes apart before every one is attached. Inhibitors exist in the laboratory; none has reached patients.","summary":"BUB1 (chromosome 2q13) is a serine/threonine kinase essential for spindle-assembly-checkpoint signalling and correct chromosome alignment: it assembles checkpoint proteins at the kinetochore, being required for the localisation of CENPF, BUB1B, CENPE and MAD2L1 and of PLK1, and for centromeric enrichment of cohesion factors. Expression is high in testis and thymus, lower in colon, spleen, lung and small intestine, and associated with tissues of high mitotic index (UniProt O43683). A ClinicalTrials.gov search for the tool inhibitor BAY 1816032 returned no studies.","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:1148","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1148"},{"label":"UniProt O43683","url":"https://www.uniprot.org/uniprotkb/O43683/entry"},{"label":"NCBI Gene 699","url":"https://www.ncbi.nlm.nih.gov/gene/699"}],"tags":["checkpoint-map"],"related":["ttk","aurkb","plk1"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["mitotic-spindle-checkpoint"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Prevalence not recorded: HGNC and UniProt carry no positivity rates."],"provenance":{"editedBy":"OnCo checkpoint map (HGNC REST, UniProt REST, ClinicalTrials.gov v2)","editedOn":"2026-09-24"},"symbol":"BUB1","role":[],"sources":[{"label":"HGNC HGNC:1148","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1148","note":"approved symbol, name, aliases and cross-references"},{"label":"UniProt O43683","url":"https://www.uniprot.org/uniprotkb/O43683/entry","note":"protein name, function and tissue specificity"}],"specificitySources":[],"hgnc":"HGNC:1148","ensembl":"ENSG00000169679","uniprot":"O43683","entrez":"699","biology":"A kinetochore kinase of the spindle assembly checkpoint, alongside MPS1 (TTK) and BUB1B.","whereFound":["Tissues with a high mitotic index (UniProt O43683)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/bub1/","neighbours":{"target":[{"id":"aurkb","kind":"target","name":"AURKB","route":"/targets/aurkb/"},{"id":"ttk","kind":"target","name":"MPS1 (TTK)","route":"/targets/ttk/"},{"id":"plk1","kind":"target","name":"PLK1","route":"/targets/plk1/"}],"pathway":[{"id":"mitotic-spindle-checkpoint","kind":"pathway","name":"Mitosis & the spindle assembly checkpoint","route":"/pathways/mitotic-spindle-checkpoint/"}],"term":[{"id":"checkpoint","kind":"term","name":"Checkpoint (two meanings)","route":"/terms/checkpoint/"}]}}