{"entity":{"id":"bub1b","kind":"target","name":"BUB1B","aka":["BUB1 mitotic checkpoint serine/threonine kinase B","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta","BUBR1","MAD3L","Bub1A","SSK1"],"tldr":"BUB1B (Mitotic checkpoint serine/threonine-protein kinase BUB1 beta) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Skin cancer, Breast cancer and 3 more.","summary":"Kinase which is a component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle. The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint. The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition.\n\nOpen Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes genetic literature 0.68, literature 0.98, genetic association 0.55, somatic mutation 0.89, animal model 0.61).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1149","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1149"},{"label":"UniProt O60566","url":"https://www.uniprot.org/uniprotkb/O60566/entry"},{"label":"NCBI Gene 701","url":"https://www.ncbi.nlm.nih.gov/gene/701"},{"label":"Ensembl ENSG00000156970","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156970"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal","skin-cancer","breast-cancer","ovarian","gastric","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["mitotic-spindle-checkpoint"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BUB1B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:1149","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1149","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O60566","url":"https://www.uniprot.org/uniprotkb/O60566/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000156970","url":"https://platform.opentargets.org/target/ENSG00000156970/associations","note":"association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: colorectal cancer 0.57, gastric cancer 0.50, ovarian cancer 0.51, melanoma 0.52, skin cancer 0.55, breast cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:1149","ensembl":"ENSG00000156970","uniprot":"O60566","entrez":"701","biology":"Kinase which is a component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle. The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint. The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition. When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase. MCC also monitors kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localisation of CENPE. Location: Cytoplasm; Nucleus; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 15q15.1 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.57 with colorectal cancer (MONDO_0005575)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)","Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056)","Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/bub1b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"pathway":[{"id":"mitotic-spindle-checkpoint","kind":"pathway","name":"Mitosis & the spindle assembly checkpoint","route":"/pathways/mitotic-spindle-checkpoint/"}]}}