{"entity":{"id":"c11orf65","kind":"target","name":"C11orf65","aka":["chromosome 11 open reading frame 65","MGC33948"],"tldr":"C11orf65 (chromosome 11 open reading frame 65) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Colorectal cancer, Ovarian cancer and 4 more.","summary":"Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network.\n\nOpen Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.07, genetic association 0.91, somatic mutation 0.87).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:28519","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28519"},{"label":"UniProt Q8NCR3","url":"https://www.uniprot.org/uniprotkb/Q8NCR3/entry"},{"label":"NCBI Gene 160140","url":"https://www.ncbi.nlm.nih.gov/gene/160140"},{"label":"Ensembl ENSG00000166323","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166323"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","colorectal","ovarian","prostate","non-hodgkin-lymphoma","gastric","urothelial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"C11orf65","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:28519","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28519","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8NCR3","url":"https://www.uniprot.org/uniprotkb/Q8NCR3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000166323","url":"https://platform.opentargets.org/target/ENSG00000166323/associations","note":"association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: colorectal cancer 0.62, gastric cancer 0.54, prostate cancer 0.54, urinary bladder cancer 0.53, ovarian cancer 0.55, non-Hodgkin lymphoma 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:28519","ensembl":"ENSG00000166323","uniprot":"Q8NCR3","entrez":"160140","biology":"Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network. Location: Cytoplasm, cytosol; Mitochondrion outer membrane (UniProt). Locus 11q22.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.65 with breast cancer (MONDO_0007254)","Colorectal cancer: Open Targets association 0.62 with colorectal cancer (MONDO_0005575)","Ovarian cancer: Open Targets association 0.55 with ovarian cancer (MONDO_0008170)","Prostate cancer: Open Targets association 0.54 with prostate cancer (MONDO_0008315)","Non-Hodgkin lymphoma: Open Targets association 0.54 with non-Hodgkin lymphoma (MONDO_0018908)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.54 with gastric cancer (MONDO_0001056)"],"targetClass":"other","prevalence":[]},"route":"/targets/c11orf65/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}