{"entity":{"id":"cacna1i","kind":"target","name":"CACNA1I","aka":["calcium voltage-gated channel subunit alpha1 I","Voltage-dependent T-type calcium channel subunit alpha-1I","Cav3.3"],"tldr":"CACNA1I (Voltage-dependent T-type calcium channel subunit alpha-1I) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.20, genetic association 0.04, clinical 0.87).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1396","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1396"},{"label":"UniProt Q9P0X4","url":"https://www.uniprot.org/uniprotkb/Q9P0X4/entry"},{"label":"NCBI Gene 8911","url":"https://www.ncbi.nlm.nih.gov/gene/8911"},{"label":"Ensembl ENSG00000100346","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100346"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.87. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CACNA1I","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:1396","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1396","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9P0X4","url":"https://www.uniprot.org/uniprotkb/Q9P0X4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000100346","url":"https://platform.opentargets.org/target/ENSG00000100346/associations","note":"association with cancer (MONDO_0004992) 0.54;  (GraphQL API, CC0)"}],"hgnc":"HGNC:1396","ensembl":"ENSG00000100346","uniprot":"Q9P0X4","entrez":"8911","biology":"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signalling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Location: Membrane (UniProt). Locus 22q13.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/cacna1i/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}