{"entity":{"id":"cadm2","kind":"target","name":"CADM2","aka":["cell adhesion molecule 2","Cell adhesion molecule 2","NECL3","Necl-3","SynCAM2","SynCAM-2","IGSF4D"],"tldr":"CADM2 (Cell adhesion molecule 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.","summary":"Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organisation, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29849","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29849"},{"label":"UniProt Q8N3J6","url":"https://www.uniprot.org/uniprotkb/Q8N3J6/entry"},{"label":"NCBI Gene 253559","url":"https://www.ncbi.nlm.nih.gov/gene/253559"},{"label":"Ensembl ENSG00000175161","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175161"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CADM2","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:29849","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29849","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8N3J6","url":"https://www.uniprot.org/uniprotkb/Q8N3J6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CADM2","url":"https://www.intogen.org/search?gene=CADM2","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:29849","ensembl":"ENSG00000175161","uniprot":"Q8N3J6","entrez":"253559","biology":"Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organisation, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus. Location: Cell membrane; Synapse; Cell projection, axon (UniProt). Locus 3p12.1 (HGNC).","whereFound":["Melanoma: IntOGen driver in 1 cohort (MEL)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/cadm2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}