{"entity":{"id":"camta1","kind":"target","name":"CAMTA1","aka":["calmodulin binding transcription activator 1","Calmodulin-binding transcription activator 1","KIAA0833"],"tldr":"CAMTA1 (Calmodulin-binding transcription activator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Prostate cancer, Breast cancer and 3 more.","summary":"Transcriptional activator.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, somatic mutation 0.84). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Leiomyosarcoma, Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18806","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18806"},{"label":"UniProt Q9Y6Y1","url":"https://www.uniprot.org/uniprotkb/Q9Y6Y1/entry"},{"label":"NCBI Gene 23261","url":"https://www.ncbi.nlm.nih.gov/gene/23261"},{"label":"Ensembl ENSG00000171735","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171735"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["sarcoma","prostate","breast-cancer","skin-cancer","lung-cancer","leiomyosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CAMTA1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18806","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18806","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6Y1","url":"https://www.uniprot.org/uniprotkb/Q9Y6Y1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000171735","url":"https://platform.opentargets.org/target/ENSG00000171735/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: skin cancer 0.52, breast cancer 0.55, lung cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen CAMTA1","url":"https://www.intogen.org/search?gene=CAMTA1","note":"driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18806","ensembl":"ENSG00000171735","uniprot":"Q9Y6Y1","entrez":"23261","biology":"Transcriptional activator. Location: Nucleus; Cytoplasm (UniProt). Locus 1p36.31-p36.23 (HGNC).","whereFound":["Sarcomas: IntOGen driver in 1 cohort (LMS)","Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)","Leiomyosarcoma: IntOGen driver in 1 cohort (LMS)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/camta1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leiomyosarcoma","kind":"cancer","name":"Leiomyosarcoma","route":"/cancers/leiomyosarcoma/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}