{"entity":{"id":"cancer-cell-line-encyclopedias","kind":"technology","name":"Cancer cell line encyclopedias and dependency maps","aka":[],"tldr":"Large public collections of cancer cell lines profiled for their genomes, drug sensitivity and gene dependencies, the reference data behind much of modern target discovery.","summary":"The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer project characterised about a thousand cell lines by sequencing, expression and drug response, and the Dependency Map (DepMap) added genome-wide CRISPR knockout screens that reveal which genes each line needs to survive. These resources identified synthetic lethal targets such as WRN in microsatellite-unstable cancers and PRMT5 in MTAP-deleted tumours, and they anchor machine-learning models of drug response.","status":"established","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Cancer_Cell_Line_Encyclopedia","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Cancer_Cell_Line_Encyclopedia"}],"tags":[],"related":[],"cancers":[],"sections":["drug-discovery","ai-computation"],"technologies":["synthetic-lethality-approaches","organoids"],"targets":["wrn","prmt5-mtap"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"principle":"Cell lines are profiled by sequencing and expression, treated with drug libraries, and screened with pooled CRISPR guides; dependencies emerge where knockout selectively kills lines with a given genotype.","strengths":["Open data used across academia and industry","Systematic discovery of synthetic lethality","Ground truth for predictive models"],"limitations":["Cell lines lack stroma and immune context","Culture-adapted lines differ from tumours","Limited representation of some cancers and ancestries"]},"route":"/technologies/cancer-cell-line-encyclopedias/","neighbours":{"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"},{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"technology":[{"id":"organoids","kind":"technology","name":"Patient-derived organoids","route":"/technologies/organoids/"},{"id":"synthetic-lethality-approaches","kind":"technology","name":"Synthetic lethality approaches","route":"/technologies/synthetic-lethality-approaches/"}],"target":[{"id":"prmt5-mtap","kind":"target","name":"PRMT5 (MTAP-deleted cancers)","route":"/targets/prmt5-mtap/"},{"id":"wrn","kind":"target","name":"WRN helicase (MSI-high cancers)","route":"/targets/wrn/"}]}}