{"entity":{"id":"cancer-prevention-pharmaceuticals","kind":"company","name":"Cancer Prevention Pharmaceuticals","aka":["Cancer Prevention Pharmaceuticals, Inc.","CPP"],"tldr":"Cancer Prevention Pharmaceuticals is a Tucson company built around eflornithine, the polyamine-blocking drug, which it tested with sulindac in phase 3 to prevent polyps in familial adenomatous polyposis.","summary":"Cancer Prevention Pharmaceuticals, founded in 2008 in Tucson, Arizona, develops eflornithine (DFMO), an ornithine decarboxylase inhibitor, for cancer prevention. Its phase 3 trials combined eflornithine with sulindac in familial adenomatous polyposis and in patients with a history of colorectal adenomas, registered on ClinicalTrials.gov under the company as lead sponsor; the combination did not reach approval, though eflornithine itself was later approved by another company for neuroblastoma maintenance.","asOf":"2026-09-11","links":[{"label":"Official website","url":"https://canprevent.com"},{"label":"ClinicalTrials.gov: trials led by Cancer Prevention Pharmaceuticals, Inc.","url":"https://clinicaltrials.gov/search?lead=Cancer%20Prevention%20Pharmaceuticals%2C%20Inc."},{"label":"Wikidata","url":"https://www.wikidata.org/wiki/Q50038303"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["colorectal"],"sections":["prevention"],"technologies":["chemoprevention"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["pivotal-trial","clinical-trial"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"Tucson, AZ","country":"US","companyType":"biotech","website":"https://canprevent.com","founded":2008,"stage":"private-large","investors":[],"funding":[]},"route":"/companies/cancer-prevention-pharmaceuticals/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"section":[{"id":"prevention","kind":"section","name":"Prevention & Risk","route":"/fronts/prevention/"}],"technology":[{"id":"chemoprevention","kind":"technology","name":"Chemoprevention & risk-reducing surgery","route":"/technologies/chemoprevention/"}],"term":[{"id":"clinical-trial","kind":"term","name":"Clinical trial","route":"/terms/clinical-trial/"},{"id":"pivotal-trial","kind":"term","name":"Pivotal (registrational) trial","route":"/terms/pivotal-trial/"}]}}