{"entity":{"id":"cant1","kind":"target","name":"CANT1","aka":["calcium activated nucleotidase 1","Soluble calcium-activated nucleotidase 1","SHAPY","SCAN-1"],"tldr":"CANT1 (Soluble calcium-activated nucleotidase 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.","summary":"Calcium-dependent nucleotidase with a preference for ribonucleosides diphosphate UDP, GDP and IDP, while having very low activity towards ADP and CDP. In vitro, it can also act with low or negligible efficiency on ribonucletides triphosphate UTP, GTP, ITP, ATP and CTP. Does not hydrolyse AMP and GMP.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Oesophageal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19721","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19721"},{"label":"UniProt Q8WVQ1","url":"https://www.uniprot.org/uniprotkb/Q8WVQ1/entry"},{"label":"NCBI Gene 124583","url":"https://www.ncbi.nlm.nih.gov/gene/124583"},{"label":"Ensembl ENSG00000171302","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171302"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["esophageal","oesophageal-adenocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CANT1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:19721","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19721","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WVQ1","url":"https://www.uniprot.org/uniprotkb/Q8WVQ1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CANT1","url":"https://www.intogen.org/search?gene=CANT1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:19721","ensembl":"ENSG00000171302","uniprot":"Q8WVQ1","entrez":"124583","biology":"Calcium-dependent nucleotidase with a preference for ribonucleosides diphosphate UDP, GDP and IDP, while having very low activity towards ADP and CDP. In vitro, it can also act with low or negligible efficiency on ribonucletides triphosphate UTP, GTP, ITP, ATP and CTP. Does not hydrolyse AMP and GMP. Involved in proteoglycan synthesis. Location: Endoplasmic reticulum membrane; Golgi apparatus, Golgi stack membrane; Cell membrane (UniProt). Locus 17q25.3 (HGNC).","whereFound":["Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)","Oesophageal and junctional adenocarcinoma: IntOGen driver in 1 cohort (ESCA)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/cant1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"}]}}